The match at the Polish capital's National Stadium kicks off at 8:45 p.m. Warsaw time.
It follows the Polish team's 2-0 away win over the Faroe Islands in its previous qualifier three days earlier under its new coach Michał Probierz.
The Poles, captained by Napoli midfielder Piotr Zieliński, go into the match missing star striker Robert Lewandowski, who has been ruled out by an ankle injury.
Poland are ranked 30th worldwide by football's governing body FIFA, while Moldova are No. 159 in the FIFA table.
The Polish team on March 24 opened its Euro 2024 qualifying campaign with a 1-3 defeat against the Czech Republic. The Poles then beat Albania 1-0 at home in their second qualifier on March 27. Poland in June lost 2-3 to Moldova in their third Euro 2024 qualifier in Chișinău.
Poland beat the Faroe Islands 2-0 in their fourth Euro 2024 qualifier in Warsaw on September 7.
Poland on September 10 lost 0-2 to Albania in their fifth Euro 2024 qualifier in Tirana, leaving fans jittery about the team's chances of qualifying for the European tournament next year.
After six rounds of fixtures, Poland are second in their qualifying Group E, with nine points, behind Albania on 13 points, having played one match more than the Czech Republic and Moldova.
The Poles will take on the Czech Republic in their last qualifier in Warsaw on November 17.
The Euro 2024 tournament will be held from June 14 to July 14, 2024 in 10 cities in Germany, with the final played at Berlin's Olympiastadion.
Poland reached the last 16 of last year's World Cup in Qatar before being eliminated by eventual runners-up France.
Probierz took over as Poland manager in the middle of last month.
(gs)
Source: IAR, PAP